Description

Propynyllithium is a highly reactive organolithium reagent, a key building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce a propynyl group, enabling the construction of complex molecular architectures and fine chemicals. This compound is essential for research and development in the pharmaceutical, agrochemical, and materials science industries, where precise carbon-carbon bond formation is critical. Propynyllithium CAS NO 4529-04-8 is typically supplied as a solution in an appropriate organic solvent to ensure stability and ease of handling.

Application

• Pharmaceutical Intermediates: Key reagent in the synthesis of active pharmaceutical ingredients (APIs) and complex heterocycles.
• Agrochemical Synthesis: Used to construct propynyl-containing molecules for novel herbicides, fungicides, and insecticides.
• Material Science & Polymer Chemistry: Serves as an initiator or monomer unit in the development of specialty polymers and advanced materials.
• Organic Synthesis & Methodology: Fundamental tool for nucleophilic addition reactions, alkylations, and the preparation of alkynes in research laboratories.
• Liquid Crystal & Electronic Chemical Production: Employed in the synthesis of organic semiconductors and liquid crystal display (LCD) components.
• Cross-Coupling Reactions: A vital precursor for generating organometallic species used in palladium-catalyzed cross-coupling processes.

Basic Information

Product Name	Propynyllithium
CAS No.	4529-04-8
Molecular Formula	C₃H₃Li
Molecular Weight	45.99 g/mol
Synonyms	Lithium propynide; 1-Propynyllithium; Prop-1-yn-1-yllithium; Propynyl lithium; Lithium acetylide, methyl-; 1-Lithio-1-propyne
EINECS	Contact for details

Quality Control

Our Propynyllithium solutions are produced under stringent quality control protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is analyzed to confirm concentration, purity, and stability. Certificates of Analysis (COA) detailing assay results, solvent content, and impurity profiles are provided. We adhere to cGMP principles where applicable to support our customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being easily oxidized (store under inert atmosphere) and hygroscopic (moisture-sensitive), this material must be stored under a dry, inert gas (argon or nitrogen) atmosphere. Store in a cool, well-ventilated place, away from heat and incompatible materials. Keep the container tightly sealed when not in use. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to slightly yellow solution
Concentration	Typically 0.5 M in specified solvent (e.g., THF, Diethyl ether)
Assay (Titration)	≥ 95%
Identification (IR/NMR)	Conforms to structure
Solvent Content (GC)	Balance
Water Content (KF)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.