Description

Cyclo(-Ala-Gly) CAS NO 4526-77-6 is a synthetic cyclic dipeptide, also known as a diketopiperazine (DKP), composed of alanine and glycine. This compound serves as a crucial pharmacophore and structural motif in medicinal chemistry and biochemistry research. It is primarily needed by pharmaceutical R&D teams, peptide synthesis specialists, and academic researchers exploring bioactive molecules and molecular recognition.

Application

• Pharmaceutical Intermediate: Serves as a core scaffold for designing novel drug candidates, particularly in oncology and neurology.
• Biochemical Research: Used as a model compound to study peptide conformation, stability, and enzyme inhibition mechanisms.
• Peptide Synthesis Building Block: Acts as a constrained unit to introduce rigidity into linear peptide chains, modifying their biological activity and metabolic stability.
• Cosmetic & Personal Care Actives: Investigated for potential use in anti-aging or skin-conditioning formulations due to its peptide nature.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Material Science: Explored as a component in the development of bio-inspired polymers and nanomaterials.

Basic Information

Product Name	Cyclo(-Ala-Gly)
CAS No.	4526-77-6
Molecular Formula	C5H8N2O2
Molecular Weight	128.13 g/mol
Synonyms	Cyclo(alanylglycine); 3-Methyl-2,5-piperazinedione; Cyclo(L-alanyl-glycine); Alanylglycine anhydride; 2,5-Diketopiperazine, 3-methyl-; DKP (Ala-Gly); L-Ala-Gly cyclic dipeptide; 3-Methylpiperazine-2,5-dione
EINECS	Contact for details

Quality Control

Our Cyclo(-Ala-Gly) is manufactured under controlled conditions to ensure batch-to-batch consistency and high purity. Quality is assured through a comprehensive suite of analytical techniques including HPLC, NMR, and MS. We provide full traceability and Certificates of Analysis (COA) are available for every batch upon request, detailing purity, identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent product degradation. Long-term storage under inert atmosphere is recommended for optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.