Description

Lithium Phenylacetylide is a highly reactive organolithium compound, widely recognized as a powerful nucleophile and base in synthetic organic chemistry. Its primary value lies in its ability to efficiently introduce the phenylacetylene moiety into target molecules, enabling the construction of complex alkynes and heterocycles. This reagent is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used for key carbon-carbon bond-forming reactions.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for creating alkynyl-substituted active pharmaceutical ingredients (APIs) and novel drug candidates.
• Agrochemical Development: Used in the synthesis of advanced fungicides, herbicides, and plant growth regulators containing acetylene functional groups.
• Material Science & Polymer Chemistry: Serves as a monomer or initiator in the production of specialty polymers, conductive materials, and liquid crystals.
• Cross-Coupling Reactions: An essential reagent in Sonogashira, Negishi, and other palladium-catalyzed cross-coupling reactions to form diaryl alkynes.
• Nucleophilic Addition Chemistry: Employed for the nucleophilic addition to carbonyl compounds (aldehydes, ketones) and epoxides to generate propargylic alcohols.
• Ligand Synthesis: Used in the preparation of sophisticated alkynyl-based ligands for catalysis and coordination chemistry.
• Organic Synthesis Research: A fundamental tool in academic and industrial R&D labs for exploring new synthetic methodologies and constructing molecular architectures.

Basic Information

Product Name	Lithium Phenylacetylide
CAS No.	4440-01-1
Molecular Formula	C8H5Li
Molecular Weight	108.04 g/mol
Synonyms	Lithium Phenylethynylide; Phenylethynyllithium; Phenylacetylene, lithium salt; Ethynylbenzene, lithium derivative; Lithium acetylide, phenyl-; Lithium (phenylethynyl); Lithium phenyl ethynide; Lithium acetylide benzene complex
EINECS	Contact for details

Quality Control

Our Lithium Phenylacetylide is manufactured under stringent process controls to ensure batch-to-batch consistency and high reactivity. Quality is verified through comprehensive analytical testing, including titration for active lithium content and GC/HPLC analysis for purity and solvent composition. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. This material is highly volatile and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures of 2°C to 8°C. Due to its nature as a strong base in organic solvent, handle and store away from moisture, acids, and oxidizing agents in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration	Typically 0.5 M in THF or other specified solvent
Assay (by Titration)	≥ 95%
Identification (IR)	Conforms to structure
Solvent Content (GC)	As per declared specification
Stability	Stable under inert atmosphere at recommended storage temperature

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.