Description

Desthiobenzylpenicillin CAS NO 4425-26-7 is a key penicillin derivative and a crucial intermediate in the synthesis of semisynthetic β-lactam antibiotics. Its primary value lies in providing the core 6-aminopenicillanic acid (6-APA) structure, which is essential for developing antibiotics with enhanced stability and efficacy against resistant bacterial strains. This compound is vital for pharmaceutical manufacturers and research institutions focused on antibiotic development, chemical synthesis, and advanced pharmaceutical research.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of various semisynthetic penicillin antibiotics.
• Antibiotic Research & Development: Used in R&D for creating new β-lactam antibiotic derivatives with improved pharmacological profiles.
• Chemical Synthesis: Acts as a building block in organic synthesis for modifying the penicillin core structure.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for antibiotic testing.
• Biochemical Studies: Utilized in studies investigating the mechanism of action and resistance patterns of β-lactam antibiotics.

Basic Information

Product Name	Desthiobenzylpenicillin
CAS No.	4425-26-7
Molecular Formula	C8H12N2O3S
Molecular Weight	216.26 g/mol
Synonyms	6-Aminopenicillanic Acid (6-APA); 6-APA; 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-amino-3,3-dimethyl-7-oxo-; 6-Aminopenicillanic acid; 6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid; Penicillanic acid, 6-amino-3,3-dimethyl-7-oxo-; NSC 45541
EINECS	224-606-5

Quality Control

Our Desthiobenzylpenicillin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product undergoes rigorous analytical testing, including HPLC, IR, and titration methods, to meet exacting standards suitable for pharmaceutical intermediate applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.