Description

Ajmaline is a potent indole alkaloid derived from the roots of *Rauwolfia serpentina* and related species. This compound is of significant interest in pharmacological research and development due to its well-characterized antiarrhythmic and sodium channel-blocking properties. It serves as a critical reference standard and active pharmaceutical ingredient (API) for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and assay development of antiarrhythmic drugs in pharmacopeial testing (e.g., USP, EP).
• Cardiac Research: A key tool compound in preclinical and clinical research for studying cardiac electrophysiology, arrhythmia mechanisms, and sodium channel pharmacology.
• Active Pharmaceutical Ingredient (API): Serves as the core active component in the formulation of specialized antiarrhythmic medications.
• Biochemical Research: Employed in studies investigating ion channel function, neuronal signaling, and the structure-activity relationships of indole alkaloids.
• Analytical Chemistry: Utilized as a high-purity standard for method development and validation in chromatographic (HPLC, LC-MS) and spectroscopic analyses.

Basic Information

Item	Detail
Product Name	Ajmaline
CAS No.	4360-12-7
Molecular Formula	C20H26N2O2
Molecular Weight	326.44 g/mol
Synonyms	Ajmaline; (+)-Ajmaline; Rauwolfine; Neoajmaline; Cardiorythmine; Gilurytmal; Aritmina; Ritmos; Ritmos Elle; 17,21α-Dihydroajmalan-17,21α-diol
EINECS	224-456-6

Quality Control

Our Ajmaline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and compliance with relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity: ≤0.5%; Total impurities: ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.