Description

H-Arg(Tos)-OH is a protected derivative of the amino acid L-arginine, where the guanidino group is shielded by a tosyl (p-toluenesulfonyl) group. This protection is crucial for enabling selective peptide bond formation in complex organic synthesis, preventing unwanted side reactions. It serves as a vital building block for researchers and manufacturers in the pharmaceutical and biotechnology sectors, particularly in the development of peptide-based therapeutics and biochemical research reagents.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the controlled assembly of peptide chains in automated synthesizers.
• Pharmaceutical Intermediates: Used in the research and production of peptide drugs targeting cardiovascular, metabolic, and oncological diseases.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, protein structure-function relationships, and signal transduction pathways.
• Custom Peptide Services: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis for clients.
• Protecting Group Chemistry: Serves as a model compound for studying tosyl group introduction and removal strategies in complex molecule synthesis.

Basic Information

Product Name	H-Arg(Tos)-OH
CAS No.	4252-32-6
Molecular Formula	C13H20N4O4S
Molecular Weight	328.39 g/mol
Synonyms	NG-Tosyl-L-arginine; L-Arginine, N2-(4-methylbenzenesulfonyl)-; Arg(Tos); H-Arg(Tos)-OH; Nω-Tosyl-L-arginine; NG-p-Toluenesulfonyl-L-arginine; Tosyl-L-arginine; (S)-2-Amino-5-((4-methylphenyl)sulfonamido)pentanoic acid
EINECS	Contact for details

Quality Control

Our H-Arg(Tos)-OH is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specific results for identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	-10.0° to -12.0° (c=1 in 1N HCl)
Chiral Purity (HPLC)	≥99.0% L-isomer
Loss on Drying	≤1.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.