Description

Ac-L-Ala-Val-Gly-L-Leu-Ome CAS NO 4249-30-3 is a synthetic, protected pentapeptide derivative, specifically an acetylated and methyl-esterified sequence. This compound serves as a crucial building block (intermediate) in advanced peptide synthesis and pharmaceutical research. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of longer, more complex peptide-based drug candidates.
• Biochemical Research: Used in studies of peptide structure-activity relationships (SAR), enzyme substrates, or receptor ligands.
• Protecting Group Chemistry: Serves as a model compound in methodological development for acetyl (Ac) and methyl ester (OMe) protection/deprotection strategies.
• Reference Standard: Employed as a chromatographic or spectroscopic standard in analytical method development and quality control laboratories.
• Custom Peptide Synthesis: A starting material for contract research organizations (CROs) and CDMOs producing custom peptides for clients.

Basic Information

Product Name	Ac-L-Ala-Val-Gly-L-Leu-OMe
CAS No.	4249-30-3
Molecular Formula	C19H34N4O6
Molecular Weight	414.50 g/mol
Synonyms	Acetyl-L-alanyl-L-valylglycyl-L-leucine methyl ester; Ac-Ala-Val-Gly-Leu-OMe; N-Acetyl-L-alanyl-L-valylglycyl-L-leucine methyl ester; L-Leucine, N-acetyl-L-alanyl-L-valylglycyl-, methyl ester; Pentapeptide derivative Ac-Ala-Val-Gly-Leu-OMe; Protected pentapeptide; A 4249-30-3
EINECS	Contact for details

Quality Control

Our Ac-L-Ala-Val-Gly-L-Leu-OMe is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, identity, and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Single Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.