Description

Trifluoromethionine CAS NO 4220-05-7 is a fluorinated analog of the essential amino acid methionine, characterized by the strategic replacement of hydrogen atoms with fluorine on the methyl group. This structural modification significantly alters its physicochemical and metabolic properties, making it a valuable tool in advanced biochemical and pharmaceutical research. It is primarily sought after by research institutions and pharmaceutical developers working on enzyme mechanism studies, metabolic pathway analysis, and the development of novel diagnostic agents or therapeutic compounds.

Application

• Biochemical Research: Used as a stable, non-radioactive tracer in metabolic studies to investigate methionine pathways and protein synthesis.
• Enzyme Inhibition Studies: Serves as a mechanism-based inhibitor or substrate analog for enzymes like methionine adenosyltransferase, aiding in structural and functional analysis.
• Pharmaceutical Development: Investigated as a potential building block for novel fluorinated pharmaceuticals or PET (Positron Emission Tomography) imaging agents.
• Proteomics & Protein Labeling: Can be incorporated into peptides or proteins to study folding, stability, and interactions using 19F NMR spectroscopy.
• Agricultural Chemistry Research: Explored in studies related to plant metabolism and the development of compounds with specific biological activity.

Basic Information

Product Name	Trifluoromethionine
CAS No.	4220-05-7
Molecular Formula	C5H8F3NO2S
Molecular Weight	203.18 g/mol
Synonyms	(S)-2-Amino-4-(trifluoromethylsulfanyl)butyric acid; L-Trifluoromethionine; 4,4,4-Trifluoro-DL-methionine; 4-(Trifluoromethylthio)-2-aminobutyric Acid; NSC 88915; DL-Trifluoromethionine; α-Amino-γ-(trifluoromethylmercapto)butyric Acid
EINECS	Contact for details

Quality Control

Our Trifluoromethionine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral assay, 1H/19F NMR for structural confirmation, and residual solvent analysis, to ensure it meets the exacting standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is sensitive to strong alkali and should be kept separate from such materials. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer) or as specified
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.