Description

Tos-Glu-Oh CAS NO 4216-80-2 is a protected amino acid derivative, specifically the tosyl (Tos) derivative of glutamic acid (Glu) with a free carboxylic acid group (Oh). This compound is a crucial building block in peptide synthesis and organic chemistry, serving as a key intermediate for the controlled introduction of glutamic acid while preventing unwanted side reactions. It is primarily utilized by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in the production of peptides, bioactive molecules, and novel drug candidates.

Application

• Peptide Synthesis: Acts as a vital protected intermediate for the solid-phase and solution-phase synthesis of complex peptides containing glutamic acid residues.
• Pharmaceutical Intermediates: Serves as a key starting material or intermediate in the research and development of new active pharmaceutical ingredients (APIs) and prodrugs.
• Bioconjugation: Used in the preparation of modified peptides and proteins for biochemical research, diagnostics, and targeted drug delivery systems.
• Organic Synthesis Building Block: Provides a selectively protected carboxylic acid functionality for constructing more complex organic molecules in medicinal chemistry.
• Biochemical Research: Employed in studies involving glutamate receptor ligands, enzyme substrates, and metabolic pathway analysis.

Basic Information

Product Name	Tos-Glu-Oh
CAS No.	4216-80-2
Molecular Formula	C₁₂H₁₅NO₆S
Molecular Weight	301.32 g/mol
Synonyms	N-Tosyl-L-glutamic Acid; (2S)-2-[(4-Methylphenyl)sulfonylamino]pentanedioic Acid; L-Glutamic Acid, N-(p-Toluenesulfonyl)-; N-p-Tosyl-L-glutamic Acid; N-Tosylglutamic Acid; Tos-Glu-OH; TOS-GLU; N-(Toluene-4-sulfonyl)-L-glutamic acid
EINECS	224-155-5

Quality Control

Our Tos-Glu-Oh is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric integrity, and identity confirmation via IR and NMR. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications. We adhere to cGMP standards where applicable to support our clients in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled accordingly to maintain stability. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Optical Rotation	Specific range provided on COA
Chiral Purity (HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.