Description

Lithium Diisopropylamide (LDA) is a highly versatile and powerful non-nucleophilic base, widely recognized for its critical role in modern synthetic organic chemistry. Its primary value lies in its ability to generate kinetic enolates with high regioselectivity, making it indispensable for complex deprotonation reactions. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries, where precise control over reaction pathways is paramount.

Application

• Generation of kinetic enolates for regioselective alkylation, acylation, and aldol reactions.
• As a strong base in the synthesis of complex natural products and active pharmaceutical ingredients (APIs).
• Deprotonation of weak carbon acids in the preparation of specialty polymers and fine chemicals.
• Key reagent in metallation and halogen-metal exchange reactions.
• Facilitating stereoselective synthesis in advanced material science and catalyst development.
• Use in process chemistry for the scalable production of high-value intermediates.

Basic Information

Product Name	Lithium Diisopropylamide
CAS No.	4111-54-0
Molecular Formula	C6H14LiN
Molecular Weight	107.12 g/mol
Synonyms	LDA; Diisopropylaminolithium; Lithium bis(1-methylethyl)amide; Lithium diisopropylamine; Lithium N,N-diisopropylamide; 2-Propanamine, N-(1-methylethyl)-, lithium salt; Lithium di-iso-propylamide
EINECS	223-901-8

Quality Control

Our Lithium Diisopropylamide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. We provide comprehensive analytical data, including titration for assay purity and impurity profiling. A Certificate of Analysis (COA) detailing identity, purity, and solution concentration is supplied with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and should be stored under an inert atmosphere (argon or nitrogen) in a cool, dry place. For solutions, maintain under an inert gas blanket. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to pale yellow
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0% (as LDA)
Concentration (Typical in solvent)	1.0 M, 2.0 M in THF/Hexanes
Free amine (as Diisopropylamine)	≤ 5.0%
Water (Karl Fischer)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.