Description

Thionicotinamide Adenine Dinucleotide is a critical biochemical cofactor and a structural analog of the essential redox coenzyme NAD+. This compound is valued for its role in modulating enzymatic activity and serving as a research tool in biochemical studies. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science research sectors for enzyme inhibition studies, metabolic pathway analysis, and as a precursor in specialized synthesis.

Application

• Biochemical Research: Used as a substrate analog in enzymatic studies to investigate dehydrogenase and reductase mechanisms.
• Pharmaceutical Development: Serves as a key intermediate or reference standard in the development of novel therapeutic agents targeting metabolic pathways.
• Enzyme Inhibition Studies: Employed to study competitive inhibition and allosteric regulation of NAD+-dependent enzymes.
• Diagnostic Reagent Manufacturing: A potential component in the formulation of diagnostic kits and assay systems for clinical and research laboratories.
• Metabolomics & Proteomics: Used as a tool compound in high-throughput screening and omics research to understand cellular metabolism.
• Academic Research: Essential for university and institutional research projects focused on biochemistry, molecular biology, and cell signaling.

Basic Information

Product Name	Thionicotinamide Adenine Dinucleotide
CAS No.	4090-29-3
Molecular Formula	C21H27N7O14P2S
Molecular Weight	695.48 g/mol
Synonyms	Thio-NAD; Thionicotinamide-adenine dinucleotide; 3-Thionicotinamide adenine dinucleotide; NAD thioanalog; TNAD; Adenosine 5'-(trihydrogen diphosphate), P'→5'-ester with 3-(aminocarbonyl)-1-β-D-ribofuranosylpyridinium, hydroxide, inner salt, 3-thio-; 3-Carbamoyl-1-β-D-ribofuranosylpyridinium hydroxide, inner salt, 5'→5'-ester with adenosine 5'-(trihydrogen diphosphate)
EINECS	223-846-2

Quality Control

Our Thionicotinamide Adenine Dinucleotide is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request. We adhere to industry best practices to support research and GMP-grade manufacturing requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a desiccated environment to prevent degradation. For long-term stability, consider storage at -20°C under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.