Description

8-Bromoguanosine is a halogenated nucleoside derivative of guanosine, where a bromine atom is substituted at the 8-position of the purine ring. This modification makes it a valuable building block and research chemical in the fields of medicinal chemistry and biochemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology industries. The compound is offered under the CAS registry number 4016-63-1.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used in studies of RNA structure, function, and modification, including cross-linking experiments and probing nucleic acid conformation.
• Medicinal Chemistry: Acts as a precursor for the synthesis of more complex molecules targeting various enzymes and receptors.
• Proteomics & Genomics: Employed in the development of diagnostic tools and probes for studying nucleic acid-protein interactions.
• Academic Research: A standard reagent for investigating the effects of halogenation on nucleoside properties and biological activity.

Basic Information

Product Name	8-Bromoguanosine
CAS No.	4016-63-1
Molecular Formula	C10H12BrN5O5
Molecular Weight	362.14 g/mol
Synonyms	8-Bromo-guanosine; Guanosine, 8-bromo-; 8-Br-Guo; 8-Bromo-9-β-D-ribofuranosylguanine; 8-Bromoguanine riboside; 8-Bromo-9-(β-D-ribofuranosyl)guanine
EINECS	223-671-7

Quality Control

Our 8-Bromoguanosine is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment to ensure traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.