Description

2-Phenyl-2-(Trifluoroacetyl)Acetonitrile is a versatile and highly functionalized organic building block characterized by its phenyl and trifluoroacetyl substituents. This compound is valued for its role as a key intermediate in the synthesis of complex heterocyclic and fluorinated molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated drug candidates, including potential kinase inhibitors and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a building block for creating specialized fluorinated polymers and liquid crystals with unique electronic or optical properties.
• Organic Synthesis Reagent: Employed in cyclization and condensation reactions to construct complex heterocycles like pyrazoles and isoxazoles.
• Chemical Research & Development: Utilized in academic and industrial R&D labs for exploring new reaction methodologies and creating compound libraries for screening.

Basic Information

Product Name	2-Phenyl-2-(Trifluoroacetyl)Acetonitrile
CAS No.	492-16-0
Molecular Formula	C11H6F3NO
Molecular Weight	225.17 g/mol
Synonyms	2-Phenyl-2-(trifluoroacetyl)acetonitrile; α-Phenyl-α-(trifluoroacetyl)acetonitrile; 2-Oxo-4-phenyl-4-(trifluoromethyl)butanenitrile; 4-Phenyl-2-oxo-4-(trifluoromethyl)butanenitrile; Benzeneacetonitrile, α-(trifluoroacetyl)-; (Trifluoroacetyl)phenylacetonitrile; 492-16-0; NSC 404087
EINECS	207-763-1

Quality Control

Our 2-Phenyl-2-(Trifluoroacetyl)Acetonitrile is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.