Description

(R)-Norapocodeine CAS NO 478-77-3 is a high-purity, chiral alkaloid derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate and reference standard for the synthesis and study of more complex opioid receptor ligands. It is primarily utilized by research institutions and pharmaceutical companies engaged in neuropharmacology, medicinal chemistry, and the development of novel analgesic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of specialized opioid analogs and potential therapeutic agents.
• Medicinal Chemistry Research: Used as a reference compound for structure-activity relationship (SAR) studies targeting central nervous system receptors.
• Analytical Reference Standard: Serves as a high-purity standard for method development and quality control in analytical laboratories (HPLC, GC-MS).
• Biochemical Research: Employed in in-vitro studies to investigate ligand-receptor interactions and signal transduction pathways.
• Process Development: Used in scaling up synthetic routes for advanced pharmaceutical ingredients (APIs) in a GMP environment.

Basic Information

Product Name	(R)-Norapocodeine
CAS No.	478-77-3
Molecular Formula	C₁₇H₁₉NO₃
Molecular Weight	285.34 g/mol
Synonyms	(R)-Norapocodeine; (5R,6R)-6-[(2R)-2-Amino-2-phenylethyl]-3-methoxy-5-methyl-4,5-epoxymorphin-7-ene; 1,2,3,4,5,6-Hexahydro-6-[(1R)-2-amino-1-phenylethyl]-11-methoxy-3-methyl-2,6-methano-3-benzazocin-8-ol; Norapocodeine, (R)-; Apocodeine Impurity; Apomorphine Related Compound
EINECS	Contact for details

Quality Control

Our (R)-Norapocodeine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ICH guidelines for stability and impurity characterization, supporting its use in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.