Description

Propanedioic Acid, Fluoro- CAS NO 473-87-0 is a specialized fluorinated derivative of malonic acid, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring a fluorine atom on the propanedioic acid backbone, makes it a valuable reagent for introducing fluorinated motifs, which are essential for modulating the physicochemical properties of target molecules. This compound is particularly sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients with enhanced metabolic stability, bioavailability, and binding affinity.

Application

• Pharmaceutical Intermediate: Key synthon for the development of fluorinated active pharmaceutical ingredients (APIs), including protease inhibitors and kinase modulators.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the fluorine atom improves lipophilicity and environmental persistence.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers and specialty chemicals with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Acts as a versatile fluorinating agent and a building block for complex molecule construction in medicinal chemistry research.
• Biochemical Research: Utilized in the study of enzyme mechanisms and as a probe in metabolic pathway analysis due to its fluorine label.

Basic Information

Product Name	Propanedioic Acid, Fluoro-
CAS No.	473-87-0
Molecular Formula	C3H3FO4
Molecular Weight	122.05 g/mol
Synonyms	Fluoromalonic Acid; 2-Fluoromalonic Acid; Fluoro-propanedioic Acid; Monofluoromalonic Acid; Propanedioic acid, 2-fluoro-; 2-Fluoropropanedioic Acid; NSC 5100; AI3-24196
EINECS	207-473-1

Quality Control

Our Propanedioic Acid, Fluoro- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) that include results from HPLC for assay and impurity profiling, NMR and IR for structural confirmation, and KF Titration for moisture content. Our quality commitment ensures the material meets the stringent requirements for research and commercial synthesis applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.