Description

Thioacetic Acid S-(2-Fluoroethyl) Ester is a specialized organosulfur and organofluorine compound, serving as a valuable bifunctional building block in advanced chemical synthesis. Its molecular structure, featuring both a thioester and a fluoroethyl group, makes it a critical reagent for introducing sulfur and fluorine motifs into target molecules. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated thioester-containing drug candidates, particularly in protease inhibitor research.
• Agrochemical Synthesis: Used in the development of novel herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Chemical Biology & Proteomics: Acts as a reactive handle for protein labeling, activity-based protein profiling (ABPP), and the development of covalent enzyme inhibitors.
• Material Science Precursor: Employed in the synthesis of functionalized polymers and surfaces with specific sulfur-fluorine properties.
• Cross-Coupling Reactions: Serves as an electrophilic coupling partner in transition metal-catalyzed reactions to form carbon-sulfur bonds.
• Fluorine Chemistry Research: A versatile reagent for exploring new methodologies in organofluorine chemistry due to its reactive thioester group.

Basic Information

Product Name	Thioacetic Acid S-(2-Fluoroethyl) Ester
CAS No.	462-31-7
Molecular Formula	C4H7FOS
Molecular Weight	122.16 g/mol
Synonyms	2-Fluoroethyl thioacetate; S-(2-Fluoroethyl) ethanethioate; Ethanethioic acid, S-(2-fluoroethyl) ester; 2-Fluoroethyl thiolacetate; Acetic acid, thio-, S-(2-fluoroethyl) ester; 1-Fluoro-2-(thioacetoxy)ethane; 2-Fluoroethyl thioacetate; 462-31-7 (CAS)
EINECS	207-326-1

Quality Control

Our Thioacetic Acid S-(2-Fluoroethyl) Ester is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep away from heat, sparks, open flames, and strong oxidizing agents. For long-term storage, consider maintaining under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.450 - 1.460
Density (g/mL, 20°C)	1.15 - 1.25

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.