Description

4-Fluoroanisole is a versatile fluorinated aromatic ether, a key building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the fluorine atom and methoxy group, enabling precise molecular modifications. This compound is essential for R&D and production in the pharmaceutical, agrochemical, and liquid crystal industries, where it serves as a critical intermediate for creating more complex, high-performance molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a fluorinated phenyl ether moiety.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and stability.
• Liquid Crystal Materials: Serves as a core building block for fluorinated liquid crystal monomers used in display technologies (LCDs).
• Organic Electronics: Employed in the research and development of organic semiconductors and electro-optical materials.
• Chemical Research: A valuable reagent in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution for introducing fluorinated anisole structures.
• Dye and Pigment Intermediate: Used in the synthesis of specialized fluorinated dyes and pigments.

Basic Information

Product Name	4-Fluoroanisole
CAS No.	459-60-9
Molecular Formula	C7H7FO
Molecular Weight	126.13 g/mol
Synonyms	1-Fluoro-4-methoxybenzene; p-Fluoroanisole; 4-Fluorophenyl methyl ether; 4-Methoxyfluorobenzene; p-Methoxyfluorobenzene; F-Anisole; 4-Fluoro-1-methoxybenzene
EINECS	207-307-4

Quality Control

Our 4-Fluoroanisole is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from strong acids and oxidizing agents. Recommended storage temperature is 2-25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Total impurities ≤ 2.0%
Density (20°C)	1.10 - 1.15 g/mL
Refractive Index (n20D)	1.485 - 1.495

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.