Description

(Difluoromethoxy)Benzene CAS NO 458-92-4 is a versatile fluorinated aromatic ether, valued for its unique chemical structure that introduces fluorine atoms into target molecules. This compound is a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its difluoromethoxy group acts as a key functional handle. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for developing new compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in medicinal chemistry for introducing metabolically stable difluoromethoxy groups.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms can improve biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated components for electronic display materials, enhancing their dielectric and optical properties.
• Polymer Modification: Employed to incorporate fluorine into polymer backbones, improving chemical resistance, thermal stability, and surface properties of specialty plastics.
• Organic Synthesis Reagent: Acts as a versatile reagent in cross-coupling reactions and nucleophilic aromatic substitutions for introducing the -OCF2H moiety.
• Flavor & Fragrance Ingredient Intermediate: Used in the synthesis of complex aromatic molecules for high-value fragrance and flavor applications.

Basic Information

Product Name	(Difluoromethoxy)Benzene
CAS No.	458-92-4
Molecular Formula	C7H6F2O
Molecular Weight	144.12 g/mol
Synonyms	Benzene, (difluoromethoxy)-; α,α-Difluoroanisole; Difluoromethyl Phenyl Ether; (Difluoromethoxy)benzene; O-(Difluoromethyl)phenol; 1-(Difluoromethoxy)benzene; Phenyl difluoromethyl ether; F2CHOPh
EINECS	Contact for details

Quality Control

Our (Difluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.