Description

3-Fluoro-4-Hydroxyphenylacetic Acid is a fluorinated aromatic carboxylic acid derivative that serves as a versatile and high-value synthetic building block. Its molecular structure, featuring both a phenolic hydroxyl and an acetic acid group ortho to a fluorine atom, makes it a critical intermediate for constructing complex molecules with tailored biological activity. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and advanced material sectors who require precise fluorination for modulating compound properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, inflammation, and metabolic disorders where fluorine substitution enhances bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators, where the fluorine atom improves lipophilicity and target binding.
• Liquid Crystal & OLED Material Research: Serves as a building block for fluorinated organic semiconductors and liquid crystal compounds, contributing to improved electronic properties and device performance.
• Bioconjugation & Probe Development: Utilized in biochemical research for creating fluorescent probes, affinity labels, and protein modification agents due to its reactive carboxylic acid and hydroxyl groups.
• Polymer Modification: Acts as a monomer or modifier for introducing fluorine and phenolic functionality into specialty polymers, enhancing chemical resistance and surface properties.
• Organic Synthesis Building Block: A versatile reagent for constructing complex aromatic and heterocyclic frameworks in medicinal and process chemistry.

Basic Information

Product Name	3-Fluoro-4-Hydroxyphenylacetic Acid
CAS No.	458-09-3
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	2-(3-Fluoro-4-hydroxyphenyl)acetic Acid; (3-Fluoro-4-hydroxyphenyl)acetic Acid; 4-Hydroxy-3-fluorophenylacetic Acid; 3-Fluoro-4-hydroxybenzeneacetic Acid; 2-(3-Fluoro-4-hydroxyphenyl)ethanoic Acid; FAHPA; 458-09-3; 3-Fluoro-4-hydroxy-α-toluic Acid
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-4-Hydroxyphenylacetic Acid adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content, to ensure it meets the exacting standards required for advanced synthetic applications. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment, and we support custom purity requirements for cGMP or other regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent absorption of atmospheric moisture. For long-term storage, consider using an inert atmosphere to minimize potential oxidation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	158°C - 162°C
Loss on Drying	≤ 0.5%
Heavy Metals (as Pb)	≤ 10 ppm
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.