Description

3-Fluorophenylacetyl Chloride is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 3-fluorophenylacetyl moiety, a key structural feature in the development of high-value compounds. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and material science industries, where precise fluorination is required to modulate biological activity and material properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides and pesticides, where the fluorine atom enhances stability and bioactivity.
• Peptide Mimetics & Modifications: Employed in peptide chemistry for acylation reactions to create novel peptide-based drug candidates.
• Liquid Crystal & Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers and liquid crystal materials.
• Chemical Research & Development: A fundamental reagent for exploring new reaction pathways and creating fluorinated compound libraries for screening.
• Dye & Pigment Manufacturing: Used in the synthesis of specialized fluorinated dyes and pigments with unique optical properties.

Basic Information

Product Name	3-Fluorophenylacetyl Chloride
CAS No.	458-04-8
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	2-(3-Fluorophenyl)acetyl Chloride; (3-Fluorophenyl)acetyl Chloride; 3-Fluorobenzeneacetyl Chloride; m-Fluorophenylacetyl Chloride; 3-Fluorophenylethanoyl Chloride; α-Chloro-3-fluoroacetophenone; 3-Fluoro-α-chloroacetophenone
EINECS	Contact for details

Quality Control

Our 3-Fluorophenylacetyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by GC/HPLC and impurity profiling, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and safety parameters is provided with every shipment to guarantee supply reliability and batch-to-batch consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.