Description

(Trifluoromethoxy)Benzene is a versatile fluorinated aromatic building block characterized by its trifluoromethoxy substituent. This compound is valued for its ability to impart unique physicochemical properties, such as enhanced lipophilicity and metabolic stability, into target molecules. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the development of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethoxy pharmacophore to modulate bioavailability and potency.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group contributes to efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a core component in the synthesis of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, enhancing electronic properties and stability.
• Polymer & Resin Modifier: Incorporated into specialty polymers and resins to improve chemical resistance, thermal stability, and surface properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions for constructing complex fluorinated aromatic systems.
• Research & Development: Essential for medicinal chemistry and material science research exploring structure-activity relationships (SAR) and new fluorinated compounds.

Basic Information

Product Name	(Trifluoromethoxy)Benzene
CAS No.	456-55-3
Molecular Formula	C7H5F3O
Molecular Weight	162.11 g/mol
Synonyms	α,α,α-Trifluoroanisole; Trifluoromethyl Phenyl Ether; Benzene, (trifluoromethoxy)-; Phenyl Trifluoromethyl Ether; 1-(Trifluoromethoxy)benzene; Anisole, α,α,α-trifluoro-; NSC 9245; F3COPh
EINECS	Contact for details

Quality Control

Our (Trifluoromethoxy)Benzene is produced under stringent quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-25°C.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Related Substances (GC)	≤ 1.0% total
Density (20°C)	~1.25 g/mL
Refractive Index (n20D)	~1.41

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.