Description

3-Fluoro-4-Methoxyphenylacetic Acid is a versatile fluorinated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the synergistic combination of the electron-donating methoxy group and the fluorine atom, which allows for precise modulation of electronic and steric properties in target molecules. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders and inflammation.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and fungicides, where the fluorine atom enhances bioavailability and metabolic stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the development of novel organic semiconductors and electro-optical materials.
• Chemical Research & Development: A valuable reagent for method development, catalysis studies, and exploring new reaction pathways in academic and industrial labs.
• Peptide Mimetics: The phenylacetic acid moiety makes it useful for constructing non-natural amino acids and peptide analogs in drug discovery.

Basic Information

Product Name	3-Fluoro-4-Methoxyphenylacetic Acid
CAS No.	452-14-2
Molecular Formula	C9H9FO3
Molecular Weight	184.16 g/mol
Synonyms	(3-Fluoro-4-methoxyphenyl)acetic Acid; 2-(3-Fluoro-4-methoxyphenyl)acetic Acid; 3-Fluoro-4-methoxybenzeneacetic Acid; 4-Methoxy-3-fluorophenylacetic Acid; NSC 403697; 3-Fluoro-4-methoxy-α-toluic Acid; 3-Fluoro-p-anisylacetic Acid; 452-14-2
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-4-Methoxyphenylacetic Acid is manufactured and tested under a strict quality management system. We ensure compliance with high-purity standards suitable for research and industrial synthesis. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed to verify identity, purity, and consistency. A Certificate of Analysis (COA) detailing all test results is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of atmospheric moisture, which may affect product quality and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	< 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.