Description

4-Chloro-2-Fluoroanisole is a versatile fluorinated aromatic ether building block of significant importance in advanced organic synthesis. Its value lies in its dual functionalization, providing reactive sites for selective substitution and enabling the construction of complex molecular architectures. This intermediate is primarily needed by the pharmaceutical and agrochemical industries for the development of active ingredients, as well as by research institutions engaged in materials science and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents contribute to biological activity and environmental persistence.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies (LCDs).
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electro-optical materials.
• Fine Chemical Synthesis: Acts as a versatile building block for creating complex fluorinated aromatic compounds in custom synthesis and contract manufacturing.
• Research & Development: Utilized in academic and industrial R&D labs for methodological studies in cross-coupling reactions and nucleophilic aromatic substitution.

Basic Information

Product Name	4-Chloro-2-Fluoroanisole
CAS No.	452-09-5
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	1-Chloro-4-fluoro-2-methoxybenzene; 2-Fluoro-4-chloroanisole; 4-Chloro-2-fluoro-1-methoxybenzene; Benzene, 1-chloro-4-fluoro-2-methoxy-; Anisole, 4-chloro-2-fluoro-; 2-Fluoro-4-chloromethoxybenzene
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Fluoroanisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical properties is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. The compound is compatible with standard organic solvent containers.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0% (Standard Grade)
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.510 - 1.520
Density (20°C)	1.28 - 1.32 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.