Description

1-Chloro-2-(Trifluoromethoxy)Benzene is a versatile halogenated aromatic building block characterized by its unique combination of chlorine and trifluoromethoxy substituents. This compound is valued for its role as a key intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs), where its structural motifs impart desirable electronic and physicochemical properties. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical synthon for the development of novel drug candidates, particularly in areas requiring fluorinated or halogenated aromatic cores.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Employed to introduce halogen and fluorine functionalities into polymers, altering their thermal stability, solubility, and chemical resistance.
• Organic Synthesis Reagent: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions in research and development.
• Dye & Pigment Intermediate: Acts as a precursor in the synthesis of specialized fluorinated dyes and pigments.

Basic Information

Product Name	1-Chloro-2-(Trifluoromethoxy)Benzene
CAS No.	450-96-4
Molecular Formula	C7H4ClF3O
Molecular Weight	196.55 g/mol
Synonyms	2-Chloro-α,α,α-trifluoroanisole; 2-Chlorophenyl trifluoromethyl ether; o-Chloro-α,α,α-trifluoroanisole; 1-Chloro-2-(trifluoromethoxy)benzene; 2-Chloro-1-(trifluoromethoxy)benzene; Benzene, 1-chloro-2-(trifluoromethoxy)-; 2-Chlorophenyl trifluoromethyl ether
EINECS	Contact for details

Quality Control

Our 1-Chloro-2-(Trifluoromethoxy)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting purity, assay, and impurity profiles are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and concentration changes. Recommended storage temperature: 2-25°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.