Description

2-Chloro-5-Fluoroanisole is a versatile halogenated anisole derivative, serving as a crucial building block in advanced organic synthesis. Its molecular structure, featuring both chloro and fluoro substituents on the methoxybenzene ring, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring halogenated aromatic ether motifs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the chloro-fluoro-anisole structure imparts specific biological activity.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials.
• Chemical Research: A valuable reagent in academic and industrial R&D for studying cross-coupling reactions, such as Suzuki and Buchwald-Hartwig aminations.
• Dye and Pigment Intermediate: Used in the synthesis of specialized dyes and pigments where halogen atoms modify color and stability properties.

Basic Information

Item	Detail
Product Name	2-Chloro-5-Fluoroanisole
CAS No.	450-89-5
Molecular Formula	C7H6ClFO
Molecular Weight	160.57 g/mol
Synonyms	1-Chloro-4-fluoro-2-methoxybenzene; 2-Chloro-5-fluoromethoxybenzene; 5-Fluoro-2-chloroanisole; 2-Methoxy-4-fluorochlorobenzene; Anisole, 2-chloro-5-fluoro-; 4-Fluoro-2-methoxychlorobenzene; 2-Chloro-5-fluorophenyl methyl ether
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Fluoroanisole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including GC/HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) documenting all critical parameters are available upon request, providing full traceability and compliance assurance for your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.30 g/cm³
Refractive Index (n20D)	~1.51

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.