Description

7-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is a versatile fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the tetrahydroquinoline scaffold, which imparts favorable pharmacological properties, and the electron-withdrawing trifluoromethyl group, enhancing metabolic stability and lipophilicity. This compound is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the creation of advanced pesticides and herbicides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for functionalized organic materials, such as ligands for catalysis or components in organic electronics.
• Chemical Biology: Employed as a probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies.
• Fluorine Chemistry: A valuable compound for studying the introduction and effects of fluorine atoms in complex molecular architectures.

Basic Information

Product Name	7-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline
CAS No.	450-62-4
Molecular Formula	C10H10F3N
Molecular Weight	201.19 g/mol
Synonyms	7-(Trifluoromethyl)-1,2,3,4-tetrahydroquinoline; 1,2,3,4-Tetrahydro-7-(trifluoromethyl)quinoline; 7-Trifluoromethyl-1,2,3,4-tetrahydroquinoline; Quinoline, 1,2,3,4-tetrahydro-7-(trifluoromethyl)-; 450-62-4; 7-(Trifluoromethyl)tetrahydroquinoline
EINECS	Contact for details

Quality Control

Our 7-(Trifluoromethyl)-1,2,3,4-Tetrahydroquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring reliable and consistent performance in critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorinating agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.