Description

5-Fluoro-2-Nitroanisole is a versatile nitroaromatic ether building block of significant importance in advanced organic synthesis. Its unique structure, featuring both an electron-withdrawing nitro group and a fluorine substituent on an anisole ring, makes it a critical intermediate for constructing complex molecules. This compound is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those containing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, pesticides, and fungicides, where the fluorine atom enhances biological activity and stability.
• Dye and Pigment Manufacturing: Serves as a building block for synthesizing specialized dyes and pigments due to its nitro and methoxy functional groups.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and polymers.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for creating complex biaryl structures.
• Academic and R&D Laboratories: Used extensively in universities and contract research organizations for methodological studies and novel compound library generation.

Basic Information

Product Name	5-Fluoro-2-Nitroanisole
CAS No.	448-19-1
Molecular Formula	C7H6FNO3
Molecular Weight	171.13 g/mol
Synonyms	1-Fluoro-2-Methoxy-4-Nitrobenzene; 2-Methoxy-5-Fluoronitrobenzene; 4-Fluoro-3-Nitroanisole; 5-Fluoro-2-Nitro-1-Methoxybenzene; 2-Nitro-5-Fluoroanisole; 5-Fluoro-2-Nitrophenyl Methyl Ether; 5-Fluoro-o-Nitroanisole
EINECS	Contact for details

Quality Control

Our 5-Fluoro-2-Nitroanisole is manufactured under strict quality management protocols. Every batch undergoes comprehensive analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	65 - 68 °C
Loss on Drying	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.