Description

2,2,2-Trifluoro-1-p-Tolylethanol is a versatile fluorinated aromatic alcohol that serves as a critical chiral building block and intermediate in advanced organic synthesis. Its unique structure, featuring a trifluoroethanol moiety attached to a p-tolyl ring, provides valuable properties for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and specialty materials industries who require high-purity intermediates for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key chiral precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system and anti-inflammatory agents.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Fluorinated component used in the design of advanced electronic display materials and organic light-emitting diodes (OLEDs) to improve performance and durability.
• Chiral Ligand & Catalyst Preparation: Starting material for synthesizing chiral auxiliaries, ligands for asymmetric catalysis, and organocatalysts.
• Advanced Polymer Monomer: Intermediate for creating specialty fluoropolymers with enhanced chemical resistance, thermal stability, and low surface energy properties.
• Chemical Research & Development: Versatile scaffold for medicinal chemistry, exploring structure-activity relationships (SAR), and developing new synthetic methodologies.

Basic Information

Product Name	2,2,2-Trifluoro-1-p-Tolylethanol
CAS No.	446-65-1
Molecular Formula	C9H9F3O
Molecular Weight	190.16 g/mol
Synonyms	α,α,α-Trifluoro-4-methylbenzenemethanol; 1-(4-Methylphenyl)-2,2,2-trifluoroethanol; p-Methyl-α,α,α-trifluorobenzyl Alcohol; 4-Methyl-α,α,α-trifluorobenzyl Alcohol; (4-Methylphenyl)trifluoromethylcarbinol; 2,2,2-Trifluoro-1-(4-methylphenyl)ethanol; 1-(4-Methylphenyl)-2,2,2-trifluoroethan-1-ol
EINECS	207-176-9

Quality Control

We supply 2,2,2-Trifluoro-1-p-Tolylethanol in various purity grades, including standard and high-purity, to meet diverse application needs. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as purity, enantiomeric excess (where applicable), and impurity profiles. We adhere to a robust quality management system to guarantee batch-to-batch consistency and supply reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.