Description

2-Fluorobenzyl Bromide is a versatile and reactive organobromine compound that serves as a critical building block in advanced organic synthesis. Its value lies in the strategic combination of a reactive benzyl bromide moiety with a fluorine substituent, enabling precise molecular construction for high-value intermediates. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries who require a reliable, high-purity reagent for introducing the 2-fluorobenzyl group.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds targeting the central nervous system and as protease inhibitors.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances biological activity and stability.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis and organocatalysts.
• Material Science Precursor: Serves as a monomer or functionalization agent in the synthesis of specialty polymers and liquid crystals.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules in drug discovery and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A fundamental reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing client-specific molecules.

Basic Information

Product Name	2-Fluorobenzyl Bromide
CAS No.	446-48-0
Molecular Formula	C7H6BrF
Molecular Weight	189.03 g/mol
Synonyms	α-Bromo-2-fluorotoluene; 1-(Bromomethyl)-2-fluorobenzene; (2-Fluorophenyl)methyl Bromide; 2-Fluorobenzyl Bromide; 2-Fluorophenylmethyl Bromide; o-Fluorobenzyl Bromide; 2-Fluorobenzylbromide; Bromomethyl-2-fluorobenzene
EINECS	207-176-6

Quality Control

Our 2-Fluorobenzyl Bromide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP, ISO, and REACH standards for global supply.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.