Description

2-Fluoropropiophenone is a versatile fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in the strategic introduction of a fluorine atom, which can dramatically alter the physicochemical and biological properties of target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), where the fluorine atom enhances metabolic stability, bioavailability, and binding affinity.
• Agrochemical Research: Used in developing new generations of herbicides, fungicides, and insecticides that benefit from the unique properties of fluorine-containing compounds.
• Material Science: Serves as a monomer or building block for specialty polymers and advanced materials with tailored surface properties and stability.
• Ligand & Catalyst Development: Employed in the preparation of fluorinated ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: An essential substrate for studying novel fluorination reactions and developing new synthetic methodologies in academic and industrial labs.
• Fine Chemical Synthesis: Used in the multi-step synthesis of complex fluorinated fragrances, dyes, and other high-value specialty chemicals.

Basic Information

Product Name	2-Fluoropropiophenone
CAS No.	446-22-0
Molecular Formula	C9H9FO
Molecular Weight	152.17 g/mol
Synonyms	1-(2-Fluorophenyl)propan-1-one; Propiophenone, 2'-fluoro-; o-Fluoropropiophenone; 2'-Fluoropropiophenone; 2-Fluorophenyl ethyl ketone; α-Fluoropropiophenone; 2-Fluorophenyl 1-propanone; 446-22-0
EINECS	207-172-9

Quality Control

Our 2-Fluoropropiophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.