Description

4-Fluoro-2-Nitroanisole is a versatile fluorinated aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring both electron-withdrawing nitro and electron-donating methoxy groups on a fluorinated benzene ring, makes it a valuable building block for creating complex molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for the development of active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of various active pharmaceutical ingredients (APIs), particularly those requiring a fluorinated aromatic core.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, pesticides, and fungicides, where the fluorine atom can enhance biological activity and stability.
• Dye and Pigment Manufacturing: Serves as an intermediate for synthesizing specialized dyes and pigments, leveraging the nitro and methoxy functional groups.
• Liquid Crystal & OLED Material Research: Employed in the development of fluorinated organic compounds for electronic display applications.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution reactions to introduce complex functionalities.
• Chemical Research & Development: A standard reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel fluorinated compounds.

Basic Information

Product Name	4-Fluoro-2-Nitroanisole
CAS No.	445-83-0
Molecular Formula	C7H6FNO3
Molecular Weight	171.13 g/mol
Synonyms	1-Fluoro-4-methoxy-3-nitrobenzene; 2-Nitro-4-fluoroanisole; 4-Fluoro-2-nitro-1-methoxybenzene; 3-Nitro-4-fluoroanisole; 4-Methoxy-3-nitrofluorobenzene; 4-Fluoro-3-nitroanisole; 4-Fluoro-2-nitro-1-methoxybenzene; 4-Fluoro-2-nitroanisole (primary name)
EINECS	207-170-5

Quality Control

Our 4-Fluoro-2-Nitroanisole is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to guarantee it meets your specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in amber glass or opaque packaging during long-term storage.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	68°C - 72°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.