Description

2'-Fluoroacetophenone is a versatile fluorinated aromatic ketone, serving as a critical building block in advanced organic synthesis. Its value lies in the introduction of the fluorine atom and the reactive carbonyl group, enabling precise molecular modifications for performance enhancement. This intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors, where it is used to develop novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of fluorinated drug candidates, including potential CNS-active molecules and enzyme inhibitors.
• Agrochemical Synthesis: Building block for developing new-generation herbicides, pesticides, and fungicides with improved efficacy and environmental profiles.
• Liquid Crystal & OLED Material Research: Used in the creation of fluorinated core structures for electronic display and lighting materials.
• Advanced Polymer Chemistry: Monomer or modifier for introducing fluorine into polymer chains to alter surface properties, stability, and solubility.
• Organic Synthesis & Catalysis: A valuable substrate for cross-coupling reactions, Grignard reactions, and reductions to access a wide array of fluorinated derivatives.
• Flavor & Fragrance Industry: Intermediate for synthesizing specific fluorinated aromatic compounds used in specialty fragrance formulations.

Basic Information

Product Name	2'-Fluoroacetophenone
CAS No.	445-27-2
Molecular Formula	C8H7FO
Molecular Weight	138.14 g/mol
Synonyms	2-Fluoroacetophenone; 1-(2-Fluorophenyl)ethanone; o-Fluoroacetophenone; 2-Fluorophenyl methyl ketone; Methyl 2-fluorophenyl ketone; 2-Acetylfluorobenzene; 2-Fluoro-1-phenylethanone; α-Fluoroacetophenone (less common)
EINECS	207-166-4

Quality Control

Our 2'-Fluoroacetophenone is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide Certificates of Analysis (COA) with detailed specifications for traceable quality assurance, supporting your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.505 - 1.515
Density (20°C)	1.14 - 1.16 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.