Description

Trifluoperazine Dihydrochloride CAS NO 440-17-5 is a high-purity pharmaceutical intermediate and active pharmaceutical ingredient (API) belonging to the phenothiazine class of antipsychotic agents. Its primary commercial value lies in its critical role as the active salt form in the formulation of antipsychotic medications, ensuring consistent pharmacological activity and stability. This compound is essential for manufacturers in the global pharmaceutical industry engaged in the production of finished dosage forms for the treatment of schizophrenia and other psychotic disorders, as well as for research institutions conducting neuropharmacological studies.

Application

• Pharmaceutical API: Primary active ingredient in the manufacture of antipsychotic medication formulations.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Clinical Research: Serves as a key compound in preclinical and clinical studies investigating dopaminergic pathways and antipsychotic efficacy.
• Generic Drug Production: Critical for generic pharmaceutical companies developing bioequivalent versions of branded antipsychotic drugs.
• Biochemical Research: Utilized in in-vitro studies to understand receptor binding mechanisms and cellular responses.

Basic Information

Product Name	Trifluoperazine Dihydrochloride
CAS No.	440-17-5
Molecular Formula	C21H24F3N3S • 2HCl
Molecular Weight	480.42 g/mol
Synonyms	Trifluoperazine HCl; Trifluoperazine Hydrochloride; 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine Dihydrochloride; Stelazine Dihydrochloride; Trifluoperazinium Dichloride; Trifluoperazine Dihydrochloride Salt; Trifluoroperazine Dihydrochloride; NSC-67695
EINECS	207-125-9

Quality Control

Our Trifluoperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting results for assay, related substances, residual solvents, and other critical parameters. We support compliance with major pharmacopoeial standards, including USP and EP, upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.