Description

Methyl Difluoroacetate CAS NO 433-53-4 is a versatile fluorinated ester building block, valued for its ability to introduce the difluoroacetate moiety into complex molecules. Its high volatility and reactivity make it a critical intermediate in the synthesis of advanced materials and active pharmaceutical ingredients (APIs). This compound is essential for R&D and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to incorporate fluorine for enhanced properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated analogs of drugs to improve metabolic stability, bioavailability, and binding affinity.
• Agrochemical Synthesis: Used in the production of novel herbicides, pesticides, and fungicides where fluorine atoms enhance activity and environmental persistence.
• Liquid Crystal & Electronic Materials: Serves as a precursor for fluorinated compounds used in liquid crystal displays (LCDs) and dielectric materials.
• Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Reagent: Acts as a difluoromethylating agent or a protected form of difluoroacetic acid in various carbon-carbon and carbon-heteroatom bond-forming reactions.
• Flavor & Fragrance Industry: Potential intermediate for creating unique fluorinated aroma chemicals, though specific applications require regulatory approval.

Basic Information

Product Name	Methyl Difluoroacetate
CAS No.	433-53-4
Molecular Formula	C3H4F2O2
Molecular Weight	110.06 g/mol
Synonyms	Difluoroacetic Acid Methyl Ester; Methyl 2,2-Difluoroacetate; Methyl 2,2-Difluoroethanoate; 2,2-Difluoroacetic Acid Methyl Ester; MDFA; Methyl Ester of Difluoroacetic Acid; NSC 9235; EINECS 207-100-5
EINECS	207-100-5

Quality Control

Our Methyl Difluoroacetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature is 2-8°C for long-term stability, though short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (20°C)	~1.25 g/mL
Boiling Point	~85-90°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.