Description

Trifluoroacetaldehyde Ethyl Hemiacetal is a versatile fluorinated building block essential for advanced organic synthesis. This compound is valued for its ability to introduce the trifluoromethyl group, a key motif that enhances the metabolic stability, lipophilicity, and bioavailability of target molecules. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating high-value intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for antiviral, anticancer, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used to manufacture advanced herbicides, fungicides, and pesticides where the trifluoromethyl group improves efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a key raw material for producing fluorinated components in electronic display technologies.
• Advanced Polymer Modification: Employed to introduce fluorine into polymer chains, enhancing material properties like chemical resistance, thermal stability, and surface characteristics.
• Organic Synthesis Reagent: Acts as a protected form of trifluoroacetaldehyde (a highly volatile gas) for safer handling in Grignard reactions, nucleophilic additions, and other complex transformations.
• Fluorinated Surfactant & Coating Additive: Used in the development of high-performance surfactants and coating additives that require low surface energy and stability.

Basic Information

Product Name	Trifluoroacetaldehyde Ethyl Hemiacetal
CAS No.	433-27-2
Molecular Formula	C4H7F3O2
Molecular Weight	144.09 g/mol
Synonyms	1-Ethoxy-2,2,2-trifluoroethanol; 2,2,2-Trifluoro-1-ethoxyethanol; Ethyl 2,2,2-Trifluoro-1-hydroxyethyl Ether; Trifluoroacetaldehyde Ethyl Hemiacetal; α,α,α-Trifluoroacetaldehyde Ethyl Hemiacetal; TFAA Ethyl Hemiacetal; 1-Ethoxy-2,2,2-trifluoroethan-1-ol (IUPAC)
EINECS	207-095-5

Quality Control

Our Trifluoroacetaldehyde Ethyl Hemiacetal is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place away from heat sources and incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, keep containers tightly sealed when not in use. Recommended storage temperature: 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	≤ 2.0% total

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.