Description

Trifluoropyruvic Acid, Monohydrate is a highly versatile fluorinated building block and a key intermediate in organic synthesis. Its value lies in the introduction of the trifluoromethyl group, a critical motif for modulating the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel fluorinated compounds.

Application

• Pharmaceutical Intermediate: A crucial precursor for synthesizing active pharmaceutical ingredients (APIs) containing the trifluoromethyl group, particularly in antiviral, anticancer, and CNS-targeted drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group enhances biological activity and environmental persistence.
• Fluorinated Building Block: Serves as a key starting material for the preparation of complex fluorinated heterocycles, amino acids, and other specialty chemicals.
• Material Science Research: Employed in the development of fluorinated polymers, liquid crystals, and electronic materials with unique properties.
• Bioconjugation & Labeling: Useful in modifying biomolecules for research purposes, leveraging its reactive carbonyl group.
• Catalysis & Ligand Development: Acts as a precursor for synthesizing novel fluorinated ligands and catalysts used in asymmetric synthesis.

Basic Information

Product Name	Trifluoropyruvic Acid, Monohydrate
CAS No.	431-72-1
Molecular Formula	C3HF3O3 • H2O
Molecular Weight	144.04 g/mol (Anhydrous basis: 126.03 g/mol)
Synonyms	2-Oxopropanoic acid, 3,3,3-trifluoro-, monohydrate; 3,3,3-Trifluoropyruvic acid monohydrate; Trifluoropyruvic acid hydrate; 3,3,3-Trifluoro-2-oxopropanoic acid monohydrate; TFP monohydrate; 2-Oxo-3,3,3-trifluoropropanoic acid hydrate; Perfluoropyruvic acid monohydrate
EINECS	207-077-9

Quality Control

Our Trifluoropyruvic Acid, Monohydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area. Due to its hygroscopic and strong acid nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to minimize moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	10.0 - 13.0% (Theoretical for monohydrate: 12.5%)
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.