Description

Trifluoroacetaldehyde Methyl Hemiacetal is a versatile fluorinated building block essential for advanced organic synthesis. Its primary value lies in its role as a stable, liquid equivalent of gaseous trifluoroacetaldehyde, enabling safer and more convenient handling in demanding chemical processes. This compound is critically needed by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries for the efficient introduction of the trifluoromethyl group into complex molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing trifluoromethyl motifs which enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the CF3 group improves efficacy and environmental profile.
• Fluorinated Material Building Block: Serves as a monomer or intermediate in the creation of specialty polymers, coatings, and liquid crystals with unique properties like chemical resistance and thermal stability.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions, Grignard reactions, and as a protecting group or masked aldehyde in multi-step synthetic routes.
• Research & Development: A fundamental reagent in medicinal chemistry and material science labs for exploring new chemical entities and fluorinated compounds.

Basic Information

Product Name	Trifluoroacetaldehyde Methyl Hemiacetal
CAS No.	431-46-9
Molecular Formula	C3H5F3O2
Molecular Weight	130.07 g/mol
Synonyms	2,2,2-Trifluoro-1-methoxyethanol; Methyl Trifluoroacetaldehyde Hemiacetal; 1-Methoxy-2,2,2-trifluoroethanol; Trifluoroacetaldehyde Methylhemiacetal; α,α,α-Trifluoroacetaldehyde Methyl Hemiacetal; TFAME; Trifluoroacetaldehyde Monomethyl Acetal (common name)
EINECS	207-081-4

Quality Control

Our Trifluoroacetaldehyde Methyl Hemiacetal is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as assay, identity, and impurity profiles. We adhere to relevant industry standards and can support customer requirements for cGMP, ISO, or other specific quality documentation upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area. Due to its highly volatile nature, keep containers tightly sealed when not in use and away from heat sources and open flames. Recommended storage temperature is 2-8°C for extended stability, although short-term storage at controlled room temperature (15-25°C) is acceptable.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.