Description

1,1,1-Trifluoro-2-Butanol is a versatile fluorinated alcohol building block of significant industrial importance. Its unique combination of fluorine atoms and a hydroxyl group makes it a valuable intermediate for synthesizing advanced materials and active pharmaceutical ingredients. This compound is particularly sought after by research and development teams in the pharmaceutical, agrochemical, and specialty chemical sectors for its ability to impart desirable properties like metabolic stability and lipophilicity to target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), especially those requiring trifluoromethyl or fluoroalkyl motifs to enhance bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms contribute to improved efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated compounds used in electronic displays and organic light-emitting diodes due to its impact on dielectric constant and molecular alignment.
• Specialty Polymer Modifier: Incorporated to alter the surface properties, chemical resistance, and thermal stability of high-performance polymers and coatings.
• Solvent & Reaction Medium: Acts as a specialty fluorinated solvent for demanding chemical reactions and separation processes.
• Research & Development: A crucial reagent in medicinal chemistry and material science research for exploring structure-activity relationships and new fluorinated compounds.

Basic Information

Product Name	1,1,1-Trifluoro-2-Butanol
CAS No.	431-36-7
Molecular Formula	C4H7F3O
Molecular Weight	128.09 g/mol
Synonyms	2-Butanol, 1,1,1-trifluoro-; 1,1,1-Trifluorobutan-2-ol; 1,1,1-Trifluoro-2-hydroxybutane; TF2B; 3,3,3-Trifluoro-2-hydroxybutane; 1,1,1-Trifluoro-sec-butanol; α-(Trifluoromethyl)propyl alcohol
EINECS	207-081-4

Quality Control

Our 1,1,1-Trifluoro-2-Butanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure it meets the high-purity standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) and highly volatile nature, containers must be kept tightly sealed after use and away from heat, sparks, and open flames. For long-term storage, consider using inert gas headspace (e.g., nitrogen or argon) to minimize moisture uptake and oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.330 - 1.340
Density (20°C)	1.20 - 1.30 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.