Description

Trifluoroacetaldehyde Hydrate is a versatile fluorinated building block essential for introducing the trifluoromethyl group into complex molecules. This compound matters for its role in enhancing the metabolic stability, lipophilicity, and bioavailability of target compounds in advanced synthesis. It is primarily needed by the pharmaceutical, agrochemical, and specialty chemical industries for the development of new active ingredients and high-value intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of trifluoromethyl-containing drugs, including antiviral and anticancer agents.
• Agrochemical Synthesis: Used in the production of advanced herbicides and pesticides where the CF3 group improves efficacy and environmental profile.
• Fluorinated Material Building Block: Serves as a starting material for specialty polymers, liquid crystals, and coatings requiring fluorinated segments.
• Organic Synthesis Reagent: Employed in nucleophilic addition reactions and as a masked form of trifluoroacetaldehyde for introducing the -CF3CHO synthon.
• Research & Development: Critical for medicinal chemistry and process chemistry research in academic and industrial laboratories.

Basic Information

Product Name	Trifluoroacetaldehyde Hydrate
CAS No.	421-53-4
Molecular Formula	C2H3F3O2
Molecular Weight	116.04 g/mol
Synonyms	2,2,2-Trifluoroacetaldehyde Hydrate; Trifluoroethanal Hydrate; 2,2,2-Trifluoro-1,1-ethanediol; Glycolic Trifluoride; Perfluoroacetaldehyde Hydrate; TFAA Hydrate; CF3CHO·H2O
EINECS	207-029-5

Quality Control

Our Trifluoroacetaldehyde Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay, impurity profiling, and identity confirmation, to ensure it meets the high-purity standards required for synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, physical properties, and test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its properties of being easily oxidized and highly volatile, it is recommended to store under an inert atmosphere and minimize exposure to air and moisture. Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.