Description

Trifluoromethylsulphenyl Chloride is a highly reactive organosulfur compound primarily used as a key building block for introducing the trifluoromethylthio (SCF₃) group. This functional group is of immense value in modern synthetic chemistry due to its strong electron-withdrawing nature and high lipophilicity, which can dramatically alter the biological activity and metabolic stability of molecules. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Critical for the synthesis of active pharmaceutical ingredients (APIs) containing the SCF₃ moiety, a privileged structure in drug discovery for its ability to improve membrane permeability and metabolic stability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethylthio group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a reagent for modifying polymer surfaces or synthesizing specialized monomers to impart unique chemical resistance or surface properties.
• Ligand and Catalyst Development: Employed in organometallic chemistry to prepare novel ligands and catalysts for asymmetric synthesis and cross-coupling reactions.
• Fluorine Chemistry Research: A fundamental reagent for academic and industrial research focused on developing new fluorination methodologies and exploring structure-activity relationships.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value specialty chemicals and dyes.

Basic Information

Product Name	Trifluoromethylsulphenyl Chloride
CAS No.	421-17-0
Molecular Formula	CF₃SCl
Molecular Weight	136.52 g/mol
Synonyms	Trifluoromethyl Sulfenyl Chloride; (Trifluoromethyl)thiohypochlorite; Perfluoromethylsulfenyl Chloride; S-Trifluoromethyl Chlorosulfenate; Trifluoromethanesulfenyl Chloride; CF₃SCl; Trifluoromethyl Chlorosulfide
EINECS	207-008-8

Quality Control

Our Trifluoromethylsulphenyl Chloride is manufactured under stringent process controls to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including Gas Chromatography (GC), NMR, and titration methods. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.