Description

Sodium 2,2,2-Trifluoroethanolate is the sodium salt derivative of 2,2,2-trifluoroethanol, serving as a powerful nucleophilic alkoxide reagent in advanced organic synthesis. This compound is critical for introducing the trifluoroethoxide group, enabling the synthesis of complex fluorinated molecules with enhanced stability and unique physicochemical properties. It is primarily utilized by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials industries for constructing novel fluorinated active ingredients and intermediates.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the preparation of fluorinated active pharmaceutical ingredients (APIs), particularly in nucleophilic substitution reactions to install the trifluoroethoxy moiety.
• Agrochemical Manufacturing: Used in the synthesis of advanced fluorinated herbicides, pesticides, and fungicides to improve metabolic stability and lipophilicity.
• Liquid Crystal & Electronic Materials: Acts as a building block for fluorinated liquid crystals and dielectric materials used in displays and electronic components.
• Polymer Modification: Employed as an initiator or modifier in the synthesis of specialty fluoropolymers with enhanced chemical and thermal resistance.
• Organic Synthesis Reagent: A versatile strong base and nucleophile for deprotonation reactions and the formation of carbon-heteroatom bonds in complex molecule construction.
• Catalyst & Ligand Preparation: Useful in the preparation of fluorinated ligands for metal catalysis and organocatalysts.

Basic Information

Product Name	Sodium 2,2,2-Trifluoroethanolate
CAS No.	420-87-1
Molecular Formula	C2H2F3NaO
Molecular Weight	128.02 g/mol
Synonyms	2,2,2-Trifluoroethanol, sodium salt; Sodium trifluoroethoxide; Trifluoroethanol sodium salt; Sodium 2,2,2-trifluoroethoxide; NaTFE; CF3CH2ONa; Trifluoroethyl alcohol, sodium derivative
EINECS	Contact for details

Quality Control

Our Sodium 2,2,2-Trifluoroethanolate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including assay by titration and impurity profiling, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and relevant parameters is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms
Assay (Titration)	≥ 95.0%
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.