Description

(E)-1,4-Difluorobut-2-Ene is a versatile fluorinated olefin building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the production of pharmaceuticals, agrochemicals, and specialty materials, enabling the introduction of fluorine atoms to modulate biological activity and physical properties. Industries such as pharmaceutical R&D, agrochemical manufacturing, and material science require this high-purity chemical for developing new active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing fluorinated active pharmaceutical ingredients (APIs) and novel drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, pesticides, and fungicides where fluorine substitution enhances efficacy and environmental stability.
• Material Science: Serves as a monomer or precursor for fluorinated polymers, coatings, and specialty materials with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in cross-coupling reactions, cycloadditions, and as a dienophile in Diels-Alder reactions to construct complex fluorinated molecular architectures.
• Liquid Crystal & Electronic Chemicals: A precursor in the manufacture of fluorinated liquid crystals and dielectric fluids for the electronics industry.

Basic Information

Product Name	(E)-1,4-Difluorobut-2-Ene
CAS No.	407-81-8
Molecular Formula	C4H6F2
Molecular Weight	92.09 g/mol
Synonyms	trans-1,4-Difluorobut-2-ene; (E)-1,4-Difluoro-2-butene; 1,4-Difluoro-2-butene (trans); trans-1,4-Difluoro-2-butene; 2-Butene, 1,4-difluoro-, (E)-; 1,4-Difluorobutene-2; But-2-ene-1,4-difluoride
EINECS	Contact for details

Quality Control

Our (E)-1,4-Difluorobut-2-Ene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to confirm identity, potency, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong acids and bases. Due to its highly volatile nature, ensure containers are kept tightly sealed and upright. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Isomeric Purity (GC)	≥ 99.0% (E-isomer)
Water Content (KF)	≤ 0.1%
Non-volatile Residue	≤ 0.05%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.