Description

2,2,2-Trifluoroethyl Trifluoroacetate is a versatile fluorinated building block and reagent of significant importance in advanced organic synthesis. Its value lies in its ability to introduce trifluoroacetate and trifluoroethoxy groups, which are critical for modifying the physical, chemical, and biological properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors, where precise fluorination is required to develop products with enhanced stability, bioavailability, or unique performance characteristics.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated motifs that improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where fluorine atoms enhance biological activity and environmental persistence.
• Fluorinated Polymer & Material Science: Serves as a monomer or modifying agent in the production of specialty polymers with enhanced chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Reagent: Acts as a trifluoroacetylating agent or protecting group in complex multi-step synthetic routes for fine chemicals and ligands.
• Liquid Crystal & Electronic Chemicals: Employed in the synthesis of fluorinated liquid crystals and dielectric fluids for the electronics industry.
• Research & Development: A valuable tool for medicinal chemistry and discovery chemistry programs exploring structure-activity relationships (SAR) through fluorination.

Basic Information

Product Name	2,2,2-Trifluoroethyl Trifluoroacetate
CAS No.	407-38-5
Molecular Formula	C4H2F6O2
Molecular Weight	196.05 g/mol
Synonyms	Trifluoroacetic Acid 2,2,2-Trifluoroethyl Ester; 2,2,2-Trifluoroethyl Trifluoroethanoate; Ethanol, 2,2,2-trifluoro-, 1,1,1-trifluoroacetate; TFETFA; TFE-TFA; Trifluoroacetic Acid Trifluoroethyl Ester; 1,1,1-Trifluoro-2-(trifluoroacetoxy)ethane
EINECS	206-983-8

Quality Control

Every batch of 2,2,2-Trifluoroethyl Trifluoroacetate is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity requirements for synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request, supporting your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatility loss.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Refractive Index (n20D)	1.300 - 1.310
Density (20°C)	1.45 - 1.55 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.