Description

Fluoroacetic Anhydride is a highly reactive acylating agent and a key fluorinated building block in organic synthesis. Its primary value lies in its ability to efficiently introduce the fluoroacetyl group, a critical moiety for modifying the biological activity and physicochemical properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where precise fluorination is required for product development.

Application

• Pharmaceutical Intermediate: Synthesis of fluorinated active pharmaceutical ingredients (APIs), including potential anticancer and antiviral agents.
• Agrochemical Synthesis: Production of novel fluorinated herbicides, pesticides, and plant growth regulators.
• Fluorinated Material Precursor: Key reagent in the development of specialty polymers, liquid crystals, and electronic chemicals.
• Biochemical Research: Used as a derivatization agent or to create fluorinated analogs of natural products for metabolic studies.
• Radiopharmaceuticals: Potential use in the synthesis of fluorine-18 labeled compounds for Positron Emission Tomography (PET) imaging.
• Organic Synthesis Reagent: A versatile fluorinating and acylating agent for constructing complex molecular architectures in R&D laboratories.

Basic Information

Product Name	Fluoroacetic Anhydride
CAS No.	407-33-0
Molecular Formula	C4H4F2O3
Molecular Weight	138.07 g/mol
Synonyms	Acetic acid, 2-fluoro-, anhydride; 2-Fluoroacetic anhydride; Bis(2-fluoroacetyl) oxide; Fluoroacetyl anhydride; Difluoroacetic anhydride (Note: This is a common misnomer, the correct structure is bis(fluoroacetyl) anhydride); Fluoroacetic acid anhydride; Monofluoroacetic anhydride
EINECS	206-983-7

Quality Control

Our Fluoroacetic Anhydride is produced under strict quality management protocols. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results for assay, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC/HPLC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.