Description

4,4,4-Trifluorobutyric Acid CAS NO 406-93-9 is a versatile fluorinated carboxylic acid building block, prized for its ability to introduce the metabolically stable trifluoromethyl group into target molecules. Its strong acidity and unique fluorine substitution pattern make it a critical intermediate for synthesizing advanced materials and bioactive compounds. This product is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries seeking to enhance the properties of their final products.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethyl motifs for improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atoms contribute to enhanced efficacy and environmental persistence.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for fluorinated compounds used in electronic displays and organic light-emitting diodes.
• Polymer & Resin Modification: Employed to introduce fluorine-containing side chains, improving chemical resistance, thermal stability, and surface properties of polymers.
• Organic Synthesis Reagent: Acts as a reagent for acylations and as a precursor for acid chlorides, esters, and amides in complex synthetic routes.
• Fluorinated Surfactant & Lubricant Production: A raw material for creating specialty surfactants and lubricants with superior performance in harsh conditions.

Basic Information

Product Name	4,4,4-Trifluorobutyric Acid
CAS No.	406-93-9
Molecular Formula	C4H5F3O2
Molecular Weight	142.08 g/mol
Synonyms	4,4,4-Trifluorobutanoic Acid; Perfluorobutyric Acid (historical); 3,3,3-Trifluoropropanecarboxylic Acid; TFBA; NSC 9235; Butanoic acid, 4,4,4-trifluoro-; 4,4,4-Trifluoro-n-butyric Acid
EINECS	206-982-9

Quality Control

Our 4,4,4-Trifluorobutyric Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including chromatography and spectroscopy, to ensure it meets high-purity standards suitable for research and industrial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 15°C and 25°C. Keep the container tightly sealed when not in use to minimize moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.355 - 1.365
Density (20°C)	1.40 - 1.45 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.