Description

4,4,4-Trifluorobutyraldehyde is a versatile fluorinated aldehyde building block essential for advanced organic synthesis. Its value lies in the unique reactivity and physicochemical properties imparted by the trifluoromethyl group, enabling the creation of novel compounds with enhanced stability and biological activity. This high-purity intermediate is critically needed by R&D and production teams in the pharmaceutical, agrochemical, and specialty materials industries for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly in antiviral, anticancer, and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine moiety improves efficacy, metabolic stability, and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials, enhancing dielectric anisotropy and thermal stability.
• Polymer & Resin Modification: Incorporated as a monomer or cross-linking agent to create fluoropolymers with superior chemical resistance, low surface energy, and thermal properties.
• Organic Synthesis Building Block: Employed in nucleophilic addition reactions, reductive amination, and as a precursor for heterocyclic compounds like fluorinated pyrroles and pyridines.
• Fluorinated Surfactant & Coating Additive: Used to synthesize surfactants and coating additives that offer improved wetting, leveling, and oil/water repellency.

Basic Information

Product Name	4,4,4-Trifluorobutyraldehyde
CAS No.	406-87-1
Molecular Formula	C4H5F3O
Molecular Weight	126.08 g/mol
Synonyms	4,4,4-Trifluorobutanal; 4,4,4-Trifluorobutyraldehyde; 4,4,4-Trifluorobutanaldehyde; 4,4,4-Trifluoro-1-butanal; 4,4,4-Trifluorobutane-1-al; 3,3,3-Trifluoropropanecarboxaldehyde; Butanal, 4,4,4-trifluoro-; 4,4,4-Trifluorobutyl Aldehyde
EINECS	206-979-5

Quality Control

Our 4,4,4-Trifluorobutyraldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, NMR, and Karl Fischer titration, to ensure it meets the highest standards of purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area at temperatures between 2°C and 8°C (refrigerated) to minimize volatility and degradation. Due to its properties of being easily oxidized (store under inert atmosphere) and highly volatile, it is recommended to handle under an inert atmosphere (e.g., nitrogen or argon) and keep containers tightly sealed when not in use. Keep away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%
Refractive Index (20°C)	1.355 - 1.365
Density (20°C)	1.25 - 1.35 g/mL

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.