Description

4,4,4-Trifluorocrotonitrile is a versatile fluorinated organic building block characterized by its reactive nitrile and trifluoromethyl groups. This compound matters for its role as a key intermediate in the synthesis of complex fluorinated molecules, which are critical for developing advanced materials and pharmaceuticals with enhanced properties. Industries such as agrochemicals, pharmaceuticals, and specialty polymers rely on this high-value synthon to introduce trifluoromethyl motifs, improving product stability and bioactivity.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for synthesizing active pharmaceutical ingredients (APIs) with trifluoromethyl groups, enhancing metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group contributes to efficacy and environmental persistence.
• Specialty Polymer & Material Science: A key monomer or modifier for creating fluorinated polymers, coatings, and electronic materials with superior chemical resistance, thermal stability, and low surface energy.
• Liquid Crystal & OLED Materials: Employed in the synthesis of fluorinated components for display and lighting technologies, improving performance and durability.
• Organic Synthesis & Catalysis: Acts as a versatile reagent in [3+2] cycloadditions and other reactions to construct complex heterocycles and fluorinated fine chemicals.
• Research & Development: Utilized in academic and industrial R&D for exploring new fluorination methodologies and creating novel chemical entities.

Basic Information

Product Name	4,4,4-Trifluorocrotonitrile
CAS No.	406-86-0
Molecular Formula	C4H2F3N
Molecular Weight	121.06 g/mol
Synonyms	4,4,4-Trifluorobut-2-enenitrile; 3,3,3-Trifluoroacrylonitrile; 2-Butenenitrile, 4,4,4-trifluoro-; 4,4,4-Trifluoro-2-butenenitrile; 4,4,4-Trifluorocrotononitrile; Trifluorocrotononitrile; (E)-4,4,4-Trifluorocrotonitrile; 4,4,4-Trifluorocrotonic acid nitrile
EINECS	Contact for details

Quality Control

Our 4,4,4-Trifluorocrotonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request, supporting compliance with global regulatory and research standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, reducing agents, and oxidizing agents. Due to its reactivity and potential volatility, handle and store under an inert atmosphere where appropriate.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.