Description

1-Bromo-4,4,4-Trifluorobutane is a versatile fluorinated organic building block, valued for its unique combination of a reactive bromine terminus and a stable trifluoromethyl group. This bifunctional nature makes it a critical intermediate for introducing fluorinated alkyl chains into target molecules, enhancing their lipophilicity and metabolic stability. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and advanced materials sectors for applications in synthesis and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: Used in the synthesis of active pharmaceutical ingredients (APIs) to incorporate the trifluoromethyl group, a key motif for improving drug potency and bioavailability.
• Agrochemical Synthesis: Serves as a key precursor for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Acts as a building block for fluorinated components in electronic display and lighting materials, improving their thermal stability and optical properties.
• Polymer Modification: Employed to introduce fluorine into polymer backbones or side chains, resulting in materials with improved chemical resistance, lower surface energy, and altered dielectric properties.
• Organic Synthesis Reagent: Functions as a versatile alkylating agent in nucleophilic substitution reactions to construct more complex fluorinated organic compounds.
• Surface Treatment & Coatings: Used in the development of specialized fluorinated coatings that provide water repellency, oil resistance, and anti-fouling characteristics.

Basic Information

Product Name	1-Bromo-4,4,4-Trifluorobutane
CAS No.	406-81-5
Molecular Formula	C4H6BrF3
Molecular Weight	191.00 g/mol
Synonyms	4-Bromo-1,1,1-trifluorobutane; Butane, 1-bromo-4,4,4-trifluoro-; 4,4,4-Trifluorobutyl bromide; 4,4,4-Trifluoro-1-bromobutane; 1,1,1-Trifluoro-4-bromobutane; 4-Bromo-1,1,1-trifluorobutane; ω-Bromo-4,4,4-trifluorobutane
EINECS	Contact for details

Quality Control

Our 1-Bromo-4,4,4-Trifluorobutane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.6 g/mL
Refractive Index (n20D)	~1.38

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.