Description

1,1,1-Trifluoro-2-Butyne is a specialized fluorinated alkyne building block of significant interest in advanced organic synthesis. Its unique structure, featuring both a terminal alkyne and a trifluoromethyl group, makes it a valuable precursor for introducing fluorine atoms into complex molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to create novel fluorinated compounds with enhanced stability, bioavailability, or performance characteristics.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging the "fluorine effect" to improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in creating novel fluorinated pesticides, herbicides, and fungicides where the introduction of fluorine can increase efficacy and environmental persistence.
• Advanced Material Precursor: Serves as a monomer or building block for fluorinated polymers, specialty coatings, and electronic materials that require specific dielectric properties or chemical resistance.
• Ligand and Catalyst Development: Employed in organometallic chemistry to develop new fluorinated ligands for catalysis, potentially enhancing reaction selectivity and efficiency.
• Fluorine-18 Radiochemistry: While not directly labeled, its structural analogs are of interest in Positron Emission Tomography (PET) tracer development for medical imaging.
• Organic Synthesis Research: A versatile reagent for click chemistry (e.g., Huisgen cycloaddition) and other C-C bond-forming reactions to create diverse fluorinated molecular libraries.

Basic Information

Product Name	1,1,1-Trifluoro-2-Butyne
CAS No.	406-41-7
Molecular Formula	C₄H₃F₃
Molecular Weight	108.06 g/mol
Synonyms	3,3,3-Trifluoro-1-butyne; 3,3,3-Trifluoroprop-1-yne; Trifluoromethylacetylene; 1-Butyne, 1,1,1-trifluoro-; 3,3,3-Trifluoro-1-propyne; CF₃C≡CH
EINECS	206-983-7

Quality Control

Every batch of 1,1,1-Trifluoro-2-Butyne is produced and analyzed under strict quality management protocols. We ensure product integrity through comprehensive analytical testing, including GC, GC-MS, NMR, and Karl Fischer titration for moisture content. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee consistency and support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile nature, store in a cool, well-ventilated place, preferably at 2-8°C. Keep away from heat, sparks, open flames, and oxidizing agents. Containers should be kept tightly sealed and upright to prevent leakage and pressure build-up.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.