Description

4-Fluorobutyric Acid Methyl Ester is a versatile fluorinated organic ester, a key building block in advanced chemical synthesis. Its value lies in its reactive ester group and the strategic fluorine atom, which are crucial for modifying molecular properties in target compounds. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A critical synthon for the preparation of fluorinated active pharmaceutical ingredients (APIs), including potential CNS agents and anticancer compounds.
• Agrochemical Synthesis: Used in the research and production of novel fluorinated pesticides and herbicides, where the fluorine atom can enhance bioavailability and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated components used in display technologies and organic electronics.
• Fluorinated Polymer Modification: Employed to introduce fluorine-containing side chains into polymers, altering surface properties, chemical resistance, and thermal stability.
• Organic Synthesis Building Block: Utilized in various reactions, such as nucleophilic substitution and reduction, to construct more complex fluorinated molecules in R&D settings.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to create complex biaryl structures common in advanced materials.

Basic Information

Product Name	4-Fluorobutyric Acid Methyl Ester
CAS No.	406-20-2
Molecular Formula	C5H9FO2
Molecular Weight	120.12 g/mol
Synonyms	Methyl 4-fluorobutanoate; 4-Fluorobutanoic Acid Methyl Ester; Methyl 4-fluorobutyrate; γ-Fluorobutyric Acid Methyl Ester; 4-Fluorobutyric Acid, Methyl Ester; Butanoic acid, 4-fluoro-, methyl ester; Methyl γ-fluorobutyrate; 406-20-2
EINECS	206-978-1

Quality Control

Our 4-Fluorobutyric Acid Methyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and identity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use. Recommended storage temperature: 2-8°C for extended stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Refractive Index (n20D)	1.395 - 1.405
Density (g/mL, 20°C)	1.05 - 1.10

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.